This is one of the most taxing ice in the game, combined with a hard end the run. That is rare enough that I would tell new players to start with this card when building corp decks of any faction.

Yes, it's Femme Fatale target #1, but put another way, it clears a Fem off the table while probably still ending the run at least once.

This costs Torch, the strongest code gate breaker in the game, 5 every time. It almost demands a Fem or Parasite + Datasuckers if the runner ever wants to see that server again. It is worth clicking for credits to pay for.

This card is very, very good.

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Femme Fatale will disable this card's run, but it will not disable the additional 3 credits you need to spend upon encountering this piece of Ice. It's still Fatale's biggest target in the early decks, but I've had a few new players get caught off-guard - thinking that all of Tollbooth's effects can be avoided even with the proper ice breakers. —
Ignore this, had some bad information when I posted it! —

Kati Jones provides a huge payoff for delaying gratification. She is ideal in a deck where your runs have some ability to fund or refund themselves, using cards like Lockpick, Desperado, and Dirty Laundry. The worst thing you can do is take credits from her every other turn, trying to recover from zero. Don't be afraid to click for credits the normal way while she charges up. When you finally take off her for X turns you get:

1 Turn: 1.5c/click

2 Turns: 2c/click

3 Turns: 2.25c/click

4 Turns: 2.4c/click

5 Turns: 2.5c/click

6 Turns: 2.57c/click

7 Turns: 2.62c/click

You'll notice two things. First, if you charge her for two turns (taking credits on the third) she is equal to Magnum Opus. This should be your baseline when deciding whether it's worth it to take the credits you need the old fashion way or off Kati. Second, after the sixth turn you get rapidly diminishing returns. Holding off until turn 8 won't help you that much more than turn 9.

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Thank you for the statistics! —